In The Adventure of the Speckled Band, Sherlock Holmes and Dr. Watson solve a case involving the murder of a young woman in a room at her stepfather's house. The woman's last words referred to a speckled band. Her sister, Helen, now stays in the same room and fears for her own safety. The stepfather, Dr. Roylott, has many exotic animals in his home, which gives Holmes a clue. Holmes and Watson spend the night in the locked room, a recurring theme in the stories, and figure out the case.