The epilogue of this novel is featured before the title page, and is only two paragraphs long. The blurb features the exact moment where Will Grayson 1 meets Will Grayson 2 later on in the novel. Both shocked and surprised, the reader is able to experience the rush of shock and confusion that these two teenagers faced when they learned that they both shared the same name. The homosexual Will Grayson 2 is quiet, and shy, and reluctant to respond to the more brooding, masculine heterosexual Will Grayson 1. This exact scene can be dissected to understand the fear and anxiety that LGBT-identifying youth face in high school, on an almost-daily basis.
The novel follows two boys who both go by the name Will Grayson. The first Will, whose POV always has correct capitalization, is described as trying to live his life without being noticed. This is complicated by the fact that his best friend, Tiny Cooper, described as "the world's largest person who is really, really gay" and "the world's gayest person who is really, really large", is not the type to go around unnoticed. Tiny is also throughout the novel trying to create an autobiographical musical, which further draws attention to himself and everyone around him.
The other Will Grayson, whose POV never has capitalization, goes through his life without anything good to hold on to besides an online relationship with someone who goes by the name Isaac. Intent on meeting up with Isaac, Will Grayson sets up an encounter one night in Chicago but eventually finds out that Isaac was invented by a girl named Maura (who is also his peer in his daily school life). What ensues brings both characters together and changes both of their lives forever in ways they could never have guessed or imagined.