Miss Lonelyhearts is a 1933 novel about a depressed newspaper columnist who writes an advice column, writing as "Miss Lonelyhearts." The novel is a black comedy that expresses a disillusioned view of American life and its alienation during the Great Depression. Through various romantic affairs Miss Lonelyhearts attempts to dispel his depression, worsened as a result of the desperate letters he reads for his column and the cynicism of his editor. In the end, Miss Lonelyhearts experiences an epiphany but is shot by the husband of his lover.

Summary of Miss Lonelyhearts by Nathanael West

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